Downregulation of Ca²⁺-Activated Cl^- Channel TMEM16A Mediated by Angiotensin II in Cirrhotic Portal Hypertensive Mice.

ABSTRACT: Portal hypertension is defined as an increased pressure in the portal venous system and occurs as a major complication in chronic liver diseases. The pathological mechanism underlying the pathogenesis and development of portal hypertension has been extensively investigated. Vascular tone of portal vein smooth muscles (PVSMs) is regulated by the activities of several ion channels, including Ca²⁺-activated Cl^- (Cl_Ca) channels. TMEM16A is mainly responsible for Cl_Ca channel conductance in vascular smooth muscle cells, including portal vein smooth muscle cells (PVSMCs). In the present study, the functional roles of TMEM16A channels were examined using two experimental portal hypertensive models, bile duct ligation (BDL) mice with cirrhotic portal hyp

SUBMITTER: Kondo R 

PROVIDER: S-EPMC8966666 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature