Epithelial Abnormalities in the Small Intestine of Zambian Children With Stunting.

ABSTRACT:

Background

Environmental enteropathy (EE) contributes to impaired linear growth (stunting), in millions of children worldwide. We have previously reported that confocal laser endomicroscopy (CLE) shows fluorescein leaking from blood to gut lumen in vivo in adults and children with EE. We set out to identify epithelial lesions which might explain this phenomenon in Zambian children with stunting non-responsive to nutritional support.

Methods

We performed confocal laser endomicroscopy (CLE) in 75 children and collected intestinal biopsies for histology in 91 children. CLE videos were evaluated, employing the Watson score to determine severity of leakiness. Morphometry was carried out on well-orientated mucosa and 3 biopsies were examined by electron microscopy.

Resul

SUBMITTER: Mulenga C 

PROVIDER: S-EPMC8966729 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature