Do Rotavirus Strains Affect Vaccine Effectiveness? A Systematic Review and Meta-analysis.

ABSTRACT:

Background

Rotavirus causes 215,000 deaths from severe childhood diarrhea annually. Concerns exist that a monovalent vaccine (RV1) and a pentavalent vaccine (RV5) may be less effective against rotavirus strains not contained in the vaccines. We estimated the vaccine effectiveness (VE) of RV1 and RV5 against severe rotavirus gastroenteritis caused by vaccine (homotypic) and nonvaccine (partially and fully heterotypic) strains.

Methods

After conducting a systematic review, we meta-analyzed 31 case-control studies (N = 27,293) conducted between 2006 and 2020 using a random-effects regression model.

Results

In high-income countries, RV1 VE was 10% lower against partially heterotypic (P = 0.04) and fully heterotypic (P = 0.10) compared with homotypic strains (homotypic VE:

SUBMITTER: Cates JE 

PROVIDER: S-EPMC8966741 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature