Bachu Mushroom Polysaccharide Alleviates Colonic Injury by Modulating the Gut Microbiota.

ABSTRACT:

Objective

This study was to define the protective effect of purified Helvella leucopus polysaccharide (p-HLP) against dextran sulfate sodium- (DSS-) induced colitis.

Methods

The novel p-HLP was isolated from Bachu mushroom through hot water extraction, ethanol precipitation, and column chromatography. Then, we evaluated the potential effects of p-HLP on colonic histopathology, inflammation, and microbiota composition in DSS-induced colitis mice.

Results

p-HLP was a homopolysaccharide with an average molecular weight of 39.14 × 10⁸ Da. Functionally, p-HLP significantly attenuated DSS-induced body weight loss and colon shortening. The histological score of the colon lesion was significantly decreased upon p-HLP treatment. Also, p-HLP treatment led to d

SUBMITTER: Abdureyim Z 

PROVIDER: S-EPMC8966746 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature