Neoadjuvant and Adjuvant Treatments Compared to Concurrent Chemoradiotherapy for Patients With Locally Advanced Cervical Cancer: A Bayesian Network Meta-Analysis.

ABSTRACT:

Aim

This study aimed to identify the most effective treatment mode for locally advanced cervical cancer (LACC) by adopting a network meta-analysis (NMA).

Methods

Randomized controlled trials about treatments were retrieved from PubMed, Medline and Embase. Odds ratios (OR) of overall survival (OS) and progression-free survival (PFS) were calculated by synthesizing direct and indirect evidence to rank the efficacy of nine treatments. Consistency was assessed by node-splitting method. Begg's test was performed to evaluate publication bias. The surface under cumulative ranking curve (SUCRA) was also used in this NMA.

Results

A total of 24 eligible randomized controlled trials with 6,636 patients were included in our NMA. These trials compared a total of nine different reg

SUBMITTER: Qiao Y 

PROVIDER: S-EPMC8966774 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature