The degenerative impact of hyperglycemia on the structure and mechanics of developing murine intervertebral discs.

ABSTRACT:

Introduction

Diabetes has long been implicated as a major risk factor for intervertebral disc (IVD) degeneration, interfering with molecular signaling and matrix biochemistry, which ultimately aggravates the progression of the disease. Glucose content has been previously shown to influence structural and compositional changes in engineered discs in vitro, impeding fiber formation and mechanical stability.

Methods

In this study, we investigated the impact of diabetic hyperglycemia on young IVDs by assessing biochemical composition, collagen fiber architecture, and mechanical behavior of discs harvested from 3- to 4-month-old db/db mouse caudal spines.

Results

We found that discs taken from diabetic mice with elevated blood glucose levels demonstrated an increase in tot

SUBMITTER: Lintz M 

PROVIDER: S-EPMC8966876 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature