Metaproteomics as a tool for studying the protein landscape of human-gut bacterial species.

ABSTRACT: Host-microbiome interactions and the microbial community have broad impact in human health and diseases. Most microbiome based studies are performed at the genome level based on next-generation sequencing techniques, but metaproteomics is emerging as a powerful technique to study microbiome functional activity by characterizing the complex and dynamic composition of microbial proteins. We conducted a large-scale survey of human gut microbiome metaproteomic data to identify generalist species that are ubiquitously expressed across all samples and specialists that are highly expressed in a small subset of samples associated with a certain phenotype. We were able to utilize the metaproteomic mass spectrometry data to reveal the protein landscapes of these species, which enables the characteri

SUBMITTER: Stamboulian M 

PROVIDER: S-EPMC8967034 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature