Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools.

ABSTRACT: Migraine is three times more prevalent in people with bipolar disorder or depression. The relationship between schizophrenia and migraine is less certain although glutamatergic and serotonergic neurotransmission are implicated in both. A shared genetic basis to migraine and mental disorders has been suggested but previous studies have reported weak or non-significant genetic correlations and five shared risk loci. Using the largest samples to date and novel statistical tools, we aimed to determine the extent to which migraine's polygenic architecture overlaps with bipolar disorder, depression and schizophrenia beyond genetic correlation, and to identify shared genetic loci. Summary statistics from genome-wide association studies were acquired from large-scale consortia for migraine (n case

SUBMITTER: Bahrami S 

PROVIDER: S-EPMC8967089 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature