Balance between competing spectral states in subthalamic nucleus is linked to motor impairment in Parkinson's disease.

ABSTRACT: Exaggerated local field potential bursts of activity at frequencies in the low beta band are a well-established phenomenon in the subthalamic nucleus of patients with Parkinson's disease. However, such activity is only moderately correlated with motor impairment. Here we test the hypothesis that beta bursts are just one of several dynamic states in the subthalamic nucleus local field potential in Parkinson's disease, and that together these different states predict motor impairment with high fidelity. Local field potentials were recorded in 32 patients (64 hemispheres) undergoing deep brain stimulation surgery targeting the subthalamic nucleus. Recordings were performed following overnight withdrawal of anti-parkinsonian medication, and after administration of levodopa. Local field potenti

SUBMITTER: Khawaldeh S 

PROVIDER: S-EPMC8967096 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature