Comorbidities in hereditary angioedema-A population-based cohort study.

ABSTRACT:

Background

In hereditary angioedema (HAE), low levels (type 1) or defect in function (type 2) of the serine-protease inhibitor C1 Inhibitor protein results in activation of the classical pathway of the complement system as well as the contact system. Here, we investigated the risk of comorbidities in HAE.

Methods

Individuals with HAE (n = 239; identified through a physician made diagnosis) and a control cohort from the general population (n = 2383; matched for age, gender, and county of residence) were compared with the Swedish inpatient, cause of death, cancer, and prescription registers. Conditional logistic regression was used to analyze the data.

Results

Increased risk of cardiovascular disease (odds ratio [OR] 1.83; 95% confidence interval [CI] 1.32-2.54), includ

SUBMITTER: Sundler Bjorkman L 

PROVIDER: S-EPMC8967273 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature