Electrical impulse characterization along actin filaments in pathological conditions.

ABSTRACT: We present an interactive Mathematica notebook that characterizes the electrical impulses along actin filaments in both muscle and non-muscle cells for a wide range of physiological and pathological conditions. The simplicity of the theoretical formulation, and high performance of the Mathematica software, enable the analysis of multiple conditions without computational restrictions. The program is based on a multi-scale (atomic → monomer → filament) approach capable of accounting for the atomistic details of a protein molecular structure, its biological environment, and their impact on the travel distance, velocity, and attenuation of monovalent ionic wave packets propagating along microfilaments. The interactive component allows investigators to choose the experimental conditions (intrac

SUBMITTER: Hunley C 

PROVIDER: S-EPMC8967275 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature