Microbiome analysis in women with endometriosis: Does a microbiome exist in peritoneal fluid and ovarian cystic fluid?

ABSTRACT:

Purpose

To investigate the relationship between the microbiome of the female genital tract and endometriosis.

Methods

This prospective cohort study included 36 women who underwent laparoscopic surgery for ovarian tumor from July 2019 to April 2020. Of them, 18 had endometriosis, and 18 did not have endometriosis. Vaginal secretions, endometrial fluid, peritoneal fluid, and ovarian cystic fluid were collected during surgery. Next-generation sequencing of bacterial 16S rRNA was performed to characterize the microbiome.

Results

Specific microbiomes were not detected in either peritoneal fluid or ovarian cystic fluid regardless of the presence or absence of endometriosis and the type of cyst. When the cutoff value of infectious bacterial abundance in the vagina was set as

SUBMITTER: Oishi S 

PROVIDER: S-EPMC8967307 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature