The APOE ^ε3/ε4 Genotype Drives Distinct Gene Signatures in the Cortex of Young Mice.

ABSTRACT:

Introduction

Restrictions on existing APOE mouse models have impacted research toward understanding the strongest genetic risk factor contributing to Alzheimer's disease (AD) and dementia, APOE^ε4 , by hindering observation of a key, common genotype in humans - APOE^ε3/ε4 . Human studies are typically underpowered to address APOE^ε4 allele risk as the APOE^ε4/ε4 genotype is rare, which leaves human and mouse research unsupported to evaluate the APOE^ε3/ε4 genotype on molecular and pathological risk for AD and dementia.

Methods

As a part of MODEL-AD, we created and validated new versions of humanized APOE^ε3/ε3 and APOE^ε4/ε4 mouse strains that, due to

SUBMITTER: Foley KE 

PROVIDER: S-EPMC8967347 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature