Steroid hormone signaling activates thermal nociception during Drosophila peripheral nervous system development.

ABSTRACT: Sensory neurons enable animals to detect environmental changes and avoid harm. An intriguing open question concerns how the various attributes of sensory neurons arise in development. Drosophila melanogaster larvae undergo a behavioral transition by robustly activating a thermal nociceptive escape behavior during the second half of larval development (third instar). The Class IV dendritic arborization (C4da) neurons are multimodal sensors which tile the body wall of Drosophila larvae and detect nociceptive temperature, light, and mechanical force. In contrast to the increase in nociceptive behavior in the third instar, we find that ultraviolet light-induced Ca²⁺ activity in C4da neurons decreases during the same period of larval development. Loss of ecdysone recept

SUBMITTER: Jaszczak JS 

PROVIDER: S-EPMC8967384 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature