Associations of Stages of Objective Memory Impairment With Amyloid PET and Structural MRI: The A4 Study.

ABSTRACT:

Background and objectives

The goal of this work was to investigate the neuroimaging correlates of the Stages of Objective Memory Impairment (SOMI) system operationalized with the Free and Cued Selective Reminding Test (FCSRT), a widely used episodic memory measure.

Methods

The FCSRT begins with a study phase in which items (e.g., grapes) are identified in response to unique semantic cues (e.g., fruit) that are used in the test phase to prompt recall of items not retrieved by free recall. There are 3 test trials of the 16 items (maximum 48). Data from 4,484 cognitively unimpaired participants from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's (A4) study were used. All participants had amyloid PET imaging, and a subset of 1,262 β-amyloid (Aβ)-positive had structural M

SUBMITTER: Grober E 

PROVIDER: S-EPMC8967421 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature