Obesity Related Glomerulopathy in Adolescent Women: The Effect of Body Surface Area.

ABSTRACT:

Background

Adolescent obesity, a risk factor for cardiorenal morbidity in adulthood, has reached epidemic proportions. Obesity-related glomerulopathy (ORG) has an early reversible stage of hyperfiltration. Age-appropriate formulae for eGFR, which are standardized to ideal body surface area (BSA) and provide assessment of kidney function in ml/min/1.73 m², may underestimate prevalence of early ORG. We investigated whether adjusting eGFR to actual BSA more readily identifies early ORG.

Methods

We studied a cohort of 22,417 young individuals, aged 12-21 years, from a New York metropolitan multi-institutional electronic health records clinical database. eGFR was calculated in two ways: BSA-standardized eGFR, and absolute eGFR. Hyperfiltration was defined above a thres

SUBMITTER: Bielopolski D 

PROVIDER: S-EPMC8967610 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature