Abnormalities in Cardiac Structure and Function among Individuals with CKD: The COMBINE Trial.

ABSTRACT:

Background

Individuals with CKD have a high burden of cardiovascular disease (CVD). Abnormalities in cardiac structure and function represent subclinical CVD and can be assessed by cardiac magnetic resonance imaging (cMRI).

Methods

We investigated differences in cMRI parameters in 140 individuals with CKD stages 3b-4 who participated in the CKD Optimal Management with BInders and NicotinamidE (COMBINE) trial and in 24 age- and sex-matched healthy volunteers. Among COMBINE participants, we examined the associations of eGFR, urine albumin-creatinine ratio (UACR), phosphate, fibroblast growth factor 23 (FGF23), and parathyroid hormone (PTH) with baseline (N=140) and 12-month change (N=112) in cMRI parameters.

Results

Mean (SD) ages of the COMBINE participan

SUBMITTER: Wang AA 

PROVIDER: S-EPMC8967624 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature