Assessment of Measurement of Salivary Urea by ATR-FTIR Spectroscopy to Screen for CKD.

ABSTRACT: Stages of CKD are currently defined by eGFR and require measurement of serum creatinine concentrations. Previous studies have shown a good correlation between salivary and serum urea levels and the stage of CKD. However, quantitative salivary urea assays in current clinical use require costly and labor-intensive commercial kits, which restricts the advantage of using saliva and limits wider applicability as a quick and easy means of assessing renal function. Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy has been shown to provide a potentially straightforward, reagent-free method for the identification of a range of disease-related biomarkers and is in current clinical use for analyses of the chemical composition of kidney stones. We assessed the feasibility

SUBMITTER: Lin TL 

PROVIDER: S-EPMC8967637 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature