Plasma copeptin is increased and associated with smaller kidney volume in young adults born very preterm.

ABSTRACT:

Background

Plasma copeptin, a surrogate marker for vasopressin levels, is increased in neonates born preterm, particularly in those with a more severe neonatal course, as reflected by bronchopulmonary dysplasia. Copeptin levels in adulthood are unknown.

Methods

In this case-control study of 101 adults born very preterm (<30 weeks of gestation) and 105 control adults born full-term, a comprehensive clinical and biological assessment was performed, including blood pressure measurements, kidney ultrasound and determination of plasma copeptin, renin activity, angiotensin II, aldosterone, apelin, sodium and potassium, serum and morning urine osmolality.

Results

The median age in the study was 23.1 years [interquartile range (IQR) 21.2-24.8] and 57% were females. In males,

SUBMITTER: Flahault A 

PROVIDER: S-EPMC8967663 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature