The development and evolution of inhibitory neurons in primate cerebrum.

ABSTRACT: Neuroanatomists have long speculated that expanded primate brains contain an increased morphological diversity of inhibitory neurons (INs)¹, and recent studies have identified primate-specific neuronal populations at the molecular level². However, we know little about the developmental mechanisms that specify evolutionarily novel cell types in the brain. Here, we reconstruct gene expression trajectories specifying INs generated throughout the neurogenic period in macaques and mice by analysing the transcriptomes of 250,181 cells. We find that the initial classes of INs generated prenatally are largely conserved among mammals. Nonetheless, we identify two contrasting developmental mechanisms for specifying evolutionarily novel cell types during prenatal development. Fi

SUBMITTER: Schmitz MT 

PROVIDER: S-EPMC8967711 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature