The effect of Glibenclamide on somatosensory evoked potentials after cardiac arrest in rats.

ABSTRACT:

Background

Science continues to search for a neuroprotective drug therapy to improve outcomes after cardiac arrest (CA). The use of glibenclamide (GBC) has shown promise in preclinical studies, but its effects on neuroprognostication tools are not well understood. We aimed to investigate the effect of GBC on somatosensory evoked potential (SSEP) waveform recovery post CA and how this relates to the early prediction of functional outcome, with close attention to arousal and somatosensory recovery, in a rodent model of CA.

Methods

Sixteen male Wistar rats were subjected to 8-min asphyxia CA and assigned to GBC treatment (n = 8) or control (n = 8) groups. GBC was administered as a loading dose of 10 μg/kg intraperitoneally 10 min after the return of spontaneous circulation, fol

SUBMITTER: Lachance BB 

PROVIDER: S-EPMC8967780 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature