DNA methylation signatures in human neonatal blood following maternal antenatal corticosteroid treatment.

ABSTRACT: Antenatal corticosteroids (ACS) are used to treat women at risk of preterm birth to improve neonatal survival. Though affected children may be at long-term risk of neurobehavioural disorders, the driving mechanisms remain unknown. Animal studies have shown that ACS exposure can lead to overlapping changes in DNA methylation between the blood and the brain, identifying gene pathways for neurodevelopment, which highlights the potential to examine peripheral blood as a surrogate for inaccessible human brain tissue. We hypothesized that differential methylation will be identified in blood of term-born neonates following ACS. Mother-infant dyads that received ACS were retrospectively identified through the Ontario Birth Study at Sinai Health Complex and matched to untreated controls for materna

SUBMITTER: Kim B 

PROVIDER: S-EPMC8967826 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature