METTL14 promotes prostate tumorigenesis by inhibiting THBS1 via an m6A-YTHDF2-dependent mechanism.
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SUBMITTER: Wang Y
PROVIDER: S-EPMC8967870 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
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METTL14 promotes prostate tumorigenesis by inhibiting THBS1 via an m6A-YTHDF2-dependent mechanism.
Wang Yongjie Y Wang Yongjie Y Chen Junfei J Gao Wei-Qiang WQ Yang Ru R
Cell death discovery 20220330 1
N6-methyladenine (m6A) is the most predominant RNA modification, which has been shown to be related to many types of cancers. However, understanding of its role in prostate cancer (PCa) is largely unknown. Here, we report an upregulation of METTL14 that was correlated with poor prognosis in PCa patients. Functionally, knocking down METTL14 inhibited tumor proliferation both in vitro and in vivo. Mechanically, RNA-seq and MeRIP-seq analyses identified THBS1 as the downstream target of METTL14 in ...[more]
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