Project description:Severe acute respiratory syndrome coronavirus (SARS-CoV) causes lethal disease in humans, which is characterized by exacerbated inflammatory response and extensive lung pathology. To address the relevance of small non-coding RNAs in SARS-CoV pathology, we deep sequenced RNAs from the lungs of infected mice and discovered three 18–22 nt small viral RNAs (svRNAs). The three svRNAs were derived from the nsp3 (svRNA-nsp3.1 and -nsp3.2) and N (svRNA-N) genomic regions of SARS-CoV. Biogenesis of CoV svRNAs was RNase III, cell type, and host species independent, but it was dependent on the extent of viral replication. Antagomir-mediated inhibition of svRNA-N significantly reduced in vivo lung pathology and pro-inflammatory cytokine expression. Taken together, these data indicate that svRNAs contribute to SARS-CoV pathogenesis and highlight the potential of svRNA-N antagomirs as antivirals.

2017-02-14 | GSE90624 | GEO

Identification and characterization of circRNAs encoded by MERS-CoV, SARS-CoV-1 and SARS-CoV-2.

Project description: Not available

| S-EPMC7799257 | biostudies-literature

SARS-CoV-Encoded Small RNAs Contribute to Infection-Associated Lung Pathology.

Project description: Not available

| S-EPMC5662013 | biostudies-literature

Identification, characterization and expression analysis of circRNA encoded by SARS-CoV-1 and SARS-CoV-2.

Project description: Not available

| S-EPMC10818166 | biostudies-literature

<i>In silico</i> analysis of SARS-CoV-2 genomes: Insights from SARS encoded non-coding RNAs.

Project description: Not available