High-resolution three-dimensional blood flow tomography in the subdiffuse regime using laser speckle contrast imaging.

ABSTRACT:

Significance

Visualizing high-resolution hemodynamics in cerebral tissue over a large field of view (FOV), provides important information in studying disease states affecting the brain. Current state-of-the-art optical blood flow imaging techniques either lack spatial resolution or are too slow to provide high temporal resolution reconstruction of flow map over a large FOV.

Aim

We present a high spatial resolution computational optical imaging technique based on principles of laser speckle contrast imaging (LSCI) for reconstructing the blood flow maps in complex tissue over a large FOV provided that the three-dimensional (3D) vascular structure is known or assumed.

Approach

Our proposed method uses a perturbation Monte Carlo simulation of the high-resolution 3D geomet

SUBMITTER: Jafari CZ 

PROVIDER: S-EPMC8968074 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature