Mutational cascade of SARS-CoV-2 leading to evolution and emergence of omicron variant.

ABSTRACT:

Background

Emergence of new variant of SARS-CoV-2, namely omicron, has posed a global concern because of its high rate of transmissibility and mutations in its genome. Researchers worldwide are trying to understand the evolution and emergence of such variants to understand the mutational cascade events.

Methods

We have considered all omicron genomes (n = 302 genomes) available till 2nd December 2021 in the public repository of GISAID along with representatives of variants of concern (VOC), i.e., alpha, beta, gamma, delta, and omicron; variant of interest (VOI) mu and lambda; and variant under monitoring (VUM). Whole genome-based phylogeny and mutational analysis were performed to understand the evolution of SARS CoV-2 leading to emergence of omicron variant.

Results

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SUBMITTER: Bansal K 

PROVIDER: S-EPMC8968180 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature