Educational level as a cause of type 2 diabetes mellitus: Caution from triangulation of observational and genetic evidence.

ABSTRACT: BACKGROUND AND OBJECTIVE: Education might be causal to type 2 diabetes mellitus (T2DM). We triangulated cohort and genetic evidence to consolidate the causality between education and T2DM.

Methods

We obtained observational evidence from the English Longitudinal Study of Ageing (ELSA). Self-reporting educational attainment was categorised as high (post-secondary and higher), middle (secondary), and low (below secondary or no academic qualifications) in 6,786 community-dwelling individuals aged ≥ 50 years without diabetes at ELSA wave 2, who were followed until wave 8 for the first diabetes diagnosis. Additionally, we performed two-sample Mendelian randomisation (MR) using an inverse-variance weighted (IVW), MR-Egger, weighted median (WM), and weighted mode-based estimate (WMBE) metho

SUBMITTER: Na-Ek N 

PROVIDER: S-EPMC8968222 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature