Chlorine Dioxide Inhibits African Swine Fever Virus by Blocking Viral Attachment and Destroying Viral Nucleic Acids and Proteins.

ABSTRACT: African swine fever (ASF) is a highly contagious disease and provokes severe economic losses and health threats. At present no effective vaccine or treatment is available to prevent or cure ASF. Consequently, there is an urgent need to develop effective drugs against ASF virus (ASFV). Chlorine dioxide (ClO₂), an ideal biocide, has broad-spectrum antibacterial activity and no drug resistance. Here, we found that ClO₂ strongly inhibited ASFV replication in porcine alveolar macrophages (PAMs). The inhibitory effect of ClO₂ occurred during viral attachment rather than entry, indicating that ClO₂ suppressed the early stage of virus life cycle. ClO₂ showed a potent anti-ASFV effect when added either before, simultaneously with, or after viru

SUBMITTER: Wei R 

PROVIDER: S-EPMC8968399 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature