Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis.

ABSTRACT:

Background

The expression of amino acid transporters is known to vary during acute pancreatitis (AP) except for LAT1 (slc7a5), the expression of which remains stable. LAT1 supports cell growth by importing leucine and thereby stimulates mammalian target of rapamycin (mTOR) activity, a phenomenon often observed in cancer cells. The mechanisms by which LAT1 influences physiological and pathophysiological processes and affects disease progression in the pancreas are not yet known.

Aim

To evaluate the role of LAT1 in the development of and recovery from AP.

Methods

AP was induced with caerulein (cae) injections in female and male mice expressing LAT1 or after its knockout (LAT1 Cre/LoxP). The development of the initial AP injury and its recovery were followed for s

SUBMITTER: Hagen CM 

PROVIDER: S-EPMC8968515 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature