Identification of New m⁶A Methylation Modification Patterns and Tumor Microenvironment Infiltration Landscape that Predict Clinical Outcomes for Papillary Renal Cell Carcinoma Patients.

ABSTRACT: N6-methyladenosine (m⁶A) is the product of the most prevalent mRNA modification in eukaryotic cells. Accumulating evidence shows that tumor microenvironment (TME) plays a pivotal role in tumor development. However, the underlying relationship between m⁶A modification and the TME of a papillary renal cell carcinoma (PRCC) is still unclear. To investigate the relationship between m⁶A modification and prognosis and immunotherapeutic efficacy for PRCC, we looked for distinct m⁶A modification patterns based on 23 m⁶A-related genes. Next, the correlation between m⁶A modification patterns and TME-related characteristics was investigated. Then, the intersected differentially expressed genes were selected and the scoring system, deno

SUBMITTER: Zheng B 

PROVIDER: S-EPMC8968637 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature