Shape features of working memory-related deep-brain regions differentiate high and low community functioning in schizophrenia.

ABSTRACT: We have previously shown that schizophrenia (SCZ) participants with high community functioning demonstrate better verbal working memory (vWM) performance relative to those with low community functioning. In the present study, we investigated whether neuroanatomical differences in regions supporting vWM also exist between schizophrenia groups that vary on community functioning. Utilizing magnetic resonance imaging, shape features of deep-brain nuclei known to be involved in vWM were calculated in samples of high functioning (HF-SCZ, n = 23) and low functioning schizophrenia participants (LF-SCZ, n = 18), as well as in a group of healthy control participants (CON, n = 45). Large deformation diffeomorphic metric mapping was employed to characterize surface anatomy of the

SUBMITTER: Alden EC 

PROVIDER: S-EPMC8968669 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature