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Rejuvenation of Tissue Stem Cells by Intrinsic and Extrinsic Factors.

ABSTRACT: Stem cell therapies, including stem cell transplantation and rejuvenation of stem cells in situ, are promising avenues for tackling a broad range of diseases. Stem cells can both self-renew and differentiate into other cell types, and play a significant role in the regulation of tissue homeostasis and regeneration after cell degeneration or injury. However, stem cell exhaustion or dysfunction increases with age and impedes the normal function of multiple tissues and systems. Thus, stem cell therapies could provide a solution to aging and age-associated diseases. Here, we discuss recent advances in understanding the mechanisms that regulate stem cell regeneration. We also summarize potential strategies for rejuvenating stem cells that leverage intrinsic and extrinsic factors. These approaches may pave the way toward therapeutic interventions aiming at extending both health and life span.

SUBMITTER: Cai Y

PROVIDER: S-EPMC8968747 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Rejuvenation of Tissue Stem Cells by Intrinsic and Extrinsic Factors.

Cai Yusheng Y Wang Si S Qu Jing J Belmonte Juan Carlos Izpisua JCI Liu Guang-Hui GH

Stem cells translational medicine 20220301 3

Stem cell therapies, including stem cell transplantation and rejuvenation of stem cells in situ, are promising avenues for tackling a broad range of diseases. Stem cells can both self-renew and differentiate into other cell types, and play a significant role in the regulation of tissue homeostasis and regeneration after cell degeneration or injury. However, stem cell exhaustion or dysfunction increases with age and impedes the normal function of multiple tissues and systems. Thus, stem cell ther ...[more]

PMID: 35303745

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