Age-Associated Risk of Liver-Related Adverse Drug Reactions.

ABSTRACT:

Objective

Aging population is generally considered more sensitive to adverse drug reactions (ADRs). Yet, big data-based quantitative evidence currently does not exist to support this concept. This study aims to investigate age-associated risks of liver-related ADR (L-ADR).

Methods

Spontaneous reporting data from 2012 to 2016 were retrieved from the China National ADR Monitoring System. The risk ratio (RR) was used to quantify the relative risk of L-ADR of each age group. The reporting odds ratio (ROR) was used to quantify the correlation with the risk of L-ADR of each drug category or drug in older adults.

Results

Totally, 64,702 L-ADR reports were retrieved, covering ages from 1 to 116, with a median age of 49. The RR values increased exponentially with the increase

SUBMITTER: Han YZ 

PROVIDER: S-EPMC8968752 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature