Butyrophilins: γδ T Cell Receptor Ligands, Immunomodulators and More.
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ABSTRACT:
SUBMITTER: Herrmann T
PROVIDER: S-EPMC8968916 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Butyrophilins: γδ T Cell Receptor Ligands, Immunomodulators and More.
Herrmann Thomas T Karunakaran Mohindar M MM
Frontiers in immunology 20220317
Butyrophilins (BTN) are relatives of the B7 family (e.g., CD80, PD-L1). They fulfill a wide range of functions including immunomodulation and bind to various receptors such as the γδ T cell receptor (γδTCR) and small molecules. One intensively studied molecule is BTN3A1, which binds <i>via</i> its cytoplasmic B30.2 domain, metabolites of isoprenoid synthesis, designated as phosphoantigen (PAg), The enrichment of PAgs in tumors or infected cells is sensed by Vγ9Vδ2 T cells, leading to the prolife ...[more]
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