Comparative microelectrode array data of the functional development of hPSC-derived and rat neuronal networks.

ABSTRACT: We present a dataset of microelectrode array (MEA) recordings from human pluripotent stem cell (hPSC)-derived and rat embryonic cortical neurons during their in vitro maturation. The data were prepared to assess extracellularly recorded spontaneous activity and to compare the functional development of these neuronal networks. In addition to recordings of spontaneous activity, we provide pharmacological responses of hPSC-derived and rat cortical cultures at their mature stage. Together with the recorded electrode raw data, we share the analysis code to form a comprehensive dataset including spike times, spike waveforms, burst activity and network synchronization metrics calculated with two different connectivity estimators. Moreover, we provide the analysis code that produced the key scient

SUBMITTER: Kapucu FE 

PROVIDER: S-EPMC8969177 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature