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Hsa_circ_0007967 promotes gastric cancer proliferation through the miR-411-5p/MAML3 axis.


ABSTRACT: Circular RNAs are an important kind of noncoding RNAs and involved in cancerogenesis, but the specific mechanism between gastric cancer and circRNAs needs further study. Hsa_circ_0007967 was selected by RNA sequencing. Here, hsa_circ_0007967 was highly expressed in gastric cancer tissues than adjacent normal tissues. Overexpressing hsa_circ_0007967 promoted gastric cancer cell proliferation in vitro and in vivo, while suppression of hsa_circ_0007967 inhibited gastric cancer cell proliferation in vitro and in vivo. Mechanistically, hsa_circ_0007967 sponged miR-411-5p to increase MAML3 expression. Overall, hsa_circ_0007967 is a promising biomarker for gastric cancer diagnosis and a potential molecule for gastric cancer treatment.

SUBMITTER: Zha Q 

PROVIDER: S-EPMC8969178 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Hsa_circ_0007967 promotes gastric cancer proliferation through the miR-411-5p/MAML3 axis.

Zha Quanbin Q   Wu Xi X   Zhang Jingxin J   Xu Tingting T   Shi YongKang Y   Sun Yayun Y   Fang Yuan Y   Gu Yunru Y   Ma Pei P   Shu Yongqian Y   Tian Shengwang S  

Cell death discovery 20220330 1


Circular RNAs are an important kind of noncoding RNAs and involved in cancerogenesis, but the specific mechanism between gastric cancer and circRNAs needs further study. Hsa_circ_0007967 was selected by RNA sequencing. Here, hsa_circ_0007967 was highly expressed in gastric cancer tissues than adjacent normal tissues. Overexpressing hsa_circ_0007967 promoted gastric cancer cell proliferation in vitro and in vivo, while suppression of hsa_circ_0007967 inhibited gastric cancer cell proliferation in  ...[more]

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