DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses.

ABSTRACT:

Background

Depression is a disabling and highly prevalent condition where genetic and epigenetic, such as DNA methylation (DNAm), differences contribute to disease risk. DNA methylation is influenced by genetic variation but the association between polygenic risk of depression and DNA methylation is unknown.

Methods

We investigated the association between polygenic risk scores (PRS) for depression and DNAm by conducting a methylome-wide association study (MWAS) in Generation Scotland (N = 8898, mean age = 49.8 years) with replication in the Lothian Birth Cohorts of 1921 and 1936 and adults in the Avon Longitudinal Study of Parents and Children (ALSPAC) (N_combined = 2049, mean age = 79.1, 69.6 and 47.2 years, respectively). We also conducted a replication MWAS in t

SUBMITTER: Shen X 

PROVIDER: S-EPMC8969265 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature