Roles of Calreticulin in Protein Folding, Immunity, Calcium Signaling and Cell Transformation.

ABSTRACT: The endoplasmic reticulum (ER) is an organelle that mediates the proper folding and assembly of proteins destined for the cell surface, the extracellular space and subcellular compartments such as the lysosomes. The ER contains a wide range of molecular chaperones to handle the folding requirements of a diverse set of proteins that traffic through this compartment. The lectin-like chaperones calreticulin and calnexin are an important class of structurally-related chaperones relevant for the folding and assembly of many N-linked glycoproteins. Despite the conserved mechanism of action of these two chaperones in nascent protein recognition and folding, calreticulin has unique functions in cellular calcium signaling and in the immune response. The ER-related functions of calreticulin in the a

SUBMITTER: Venkatesan A 

PROVIDER: S-EPMC8969281 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature