Identification and validation of a prognostic model for melanoma patients with 9 ferroptosis-related gene signature.

ABSTRACT:

Background

Melanoma is a highly heterogeneous and aggressive cutaneous malignancy. Ferroptosis, a new pathway of cell death depending on the intracellar iron, has been shown to be significantly associated with apoptosis of a number of tumors, including melanoma. Nevertheless, the relationship between ferroptosis-related genes (FRGs) and the melanoma patients' prognosis needs to be explored.

Methods

Download expression profiles of FRGs and clinical data from The Cancer Genome Atlas (TCGA) database. 70% data were randomly selected from the TCGA database and utilized the univariate Cox analysis and the least absolute shrinkage and selection operator (LASSO) regression model to create a prognostic model, and the remaining 30% was used to validate the predictive power of the mode

SUBMITTER: Chen Y 

PROVIDER: S-EPMC8969311 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature