High expression of p62/SQSTM1 predicts shorter survival for patients with pancreatic cancer.

ABSTRACT:

Background

Accumulation of the signal adaptor protein p62 has been demonstrated in many forms of cancer, including pancreatic ductal adenocarcinoma (PDAC). Although data from experimental studies suggest that p62 accumulation accelerates the development of PDAC, the association between p62 protein expression and survival in PDAC patients is unclear.

Methods

Thirty-three tumor specimens from PDAC patients treated by primary surgery were obtained. Immunohistochemical expression of p62, microtubule-associated protein 1A/1B-light chain 3 (LC3), and nuclear factor-erythroid factor 2-related factor 2 (NRF2) in tumor tissue was examined for associations with clinicopathological characteristics and disease-specific survival (DSS).

Results

There was no association between p62

SUBMITTER: Philipson E 

PROVIDER: S-EPMC8969328 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature