APOE ε4, Alzheimer's disease neuropathology and sleep disturbance, in individuals with and without dementia.

ABSTRACT:

Background

Apolipoprotein E epsilon 4 (APOE-ε4) carrier status is an established risk factor for Alzheimer's disease (AD) dementia. It has also been linked with sleep disturbance in healthy older adults and increased insomnia risk. This association may be driven by the effect of APOE-ε4 on AD pathological change, itself associated with sleep abnormalities. To assess this relationship, we have evaluated post-mortem neuropathological findings in patients with and without cognitive impairment and AD pathology, who had extensive clinical assessment within 12 months of death.

Methods

This retrospective cohort study used UK Brain Banks Network data. Eligible subjects were aged over 50, with pre-mortem neuropsychiatry inventory scores of sleep disturbance (NPI-K), neurocognitive te

SUBMITTER: Blackman J 

PROVIDER: S-EPMC8969347 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature