Effects of Antidiabetic Drugs on Endothelial Function in Patients With Type 2 Diabetes Mellitus: A Bayesian Network Meta-Analysis.

ABSTRACT:

Background

The changes of endothelial function in type 2 diabetes mellitus (T2DM) patients are closely associated with the development of cardiovascular disease (CVD). However, it is still unclear whether commonly used antidiabetic drugs can improve endothelial function. Flow-mediated dilation (FMD) is a noninvasive tool for evaluating endothelial function, which typically examines changes in the brachial artery diameter in response to ischemia using ultrasound. We performed a network meta-analysis (NMA) to explore the associations between changes in endothelial function and antidiabetic drugs by evaluating FMD in T2DM patients.

Methods

We systematically searched several electronic databases for randomized controlled trials (RCTs) published from inception until January 25, 2

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8969579 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature