Inter-regional BOLD signal variability is an organizational feature of functional brain networks.

ABSTRACT: Neuronal variability patterns promote the formation and organization of neural circuits. Macroscale similarities in regional variability patterns may therefore be linked to the strength and topography of inter-regional functional connections. To assess this relationship, we used multi-echo resting-state fMRI and investigated macroscale connectivity-variability associations in 154 adult humans (86 women; mean age = 22yrs). We computed inter-regional measures of moment-to-moment BOLD signal variability and related them to inter-regional functional connectivity. Region pairs that showed stronger functional connectivity also showed similar BOLD signal variability patterns, independent of inter-regional distance and structural similarity. Connectivity-variability associations were predominant w

SUBMITTER: Baracchini G 

PROVIDER: S-EPMC8970039 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature