Porcine Plasmacytoid Dendritic Cells Are Unique in Their Expression of a Functional NKp46 Receptor.

ABSTRACT: The activating receptor NKp46 shows a unique expression pattern on porcine leukocytes. We showed already that in swine not all NK cells express NKp46 and that CD3⁺NKp46⁺ lymphocytes form a T-cell subset with unique functional properties. Here we demonstrate the expression of NKp46 on CD4^highCD14^-CD172a⁺ porcine plasmacytoid dendritic cells (pDCs). Multicolor flow cytometry analyses revealed that the vast majority of porcine pDCs (94.2% ± 4) express NKp46 ex vivo and have an increased expression on the single-cell level compared to NK cells. FSC/SSC^highCD4^highNKp46⁺ cells produced high levels of IFN-α after CpG ODN 2216 stimulation, a hallmark of pDC function. Following receptor triggering with pl

SUBMITTER: Mair KH 

PROVIDER: S-EPMC8970115 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature