Equine Umbilical Cord Serum Composition and Its Healing Effects in Equine Corneal Ulceration.

ABSTRACT:

Background

Human autologous serum (AS) and umbilical cord serum (UCS) both contain growth and neurotrophic factors that promote corneal healing.

Aim

Our objectives were to compare equine AS and UCS cytokine and growth factor profiles and to assess the safety and clinical feasibility of the therapeutic use of UCS eye drops in cases of spontaneous complex ulcers.

Study design

Prospective clinical trial.

Methods

Vitamin A insulin growth factor, platelet-derived growth factor-BB, transforming growth factor (TGF)-β1 (enzyme-linked immunosorbent assay), interleukin (IL)-1β, IL-6, interferon-γ, and monocyte chemoattractant protein 1 concentrations were determined in 10 AS collected from different horses and 10 UCS sampled at delivery. Six client-owned horses presentin

SUBMITTER: Peyrecave-Capo X 

PROVIDER: S-EPMC8970184 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature