Mining Electronic Health Records for Drugs Associated With 28-day Mortality in COVID-19: Pharmacopoeia-wide Association Study (PharmWAS).

ABSTRACT:

Background

Patients hospitalized for a given condition may be receiving other treatments for other contemporary conditions or comorbidities. The use of such observational clinical data for pharmacological hypothesis generation is appealing in the context of an emerging disease but particularly challenging due to the presence of drug indication bias.

Objective

With this study, our main objective was the development and validation of a fully data-driven pipeline that would address this challenge. Our secondary objective was to generate pharmacological hypotheses in patients with COVID-19 and demonstrate the clinical relevance of the pipeline.

Methods

We developed a pharmacopeia-wide association study (PharmWAS) pipeline inspired from the PheWAS methodology, which system

SUBMITTER: Lerner I 

PROVIDER: S-EPMC8970341 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature