Glutamatergic metabolites among adolescents at risk for psychosis.

ABSTRACT: Proton-Magnetic Resonance Spectroscopy (¹H-MRS) may serve as an important tool for identifying biomarkers that aid the understanding of early psychosis, as development of this condition may be associated with metabolite concentration changes that reflect an alteration in glutamatergic mechanisms. The current study explored ¹H-MRS metabolite concentrations in the striatum and anterior cingulate cortex (ACC) as potential biomarkers of psychosis-risk symptom severity. In a sample of 12 adolescents at clinical high-risk for psychosis, the subclinical symptom of grandiosity significantly correlated with glutamate in the ACC. Striatal glutathione, a marker of oxidative stress linked to the glutamatergic system, significantly correlated with grandiosity. Anterior cingulate g

SUBMITTER: Demro C 

PROVIDER: S-EPMC8970349 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature