Decreased Renal Gluconeogenesis Is a Hallmark of Chronic Kidney Disease.

ABSTRACT:

Introduction

CKD is associated with alterations of tubular function. Renal gluconeogenesis is responsible for 40% of systemic gluconeogenesis during fasting, but how and why CKD affects this process and the repercussions of such regulation are unknown.

Methods

We used data on the renal gluconeogenic pathway from more than 200 renal biopsies performed on CKD patients and from 43 kidney allograft patients, and studied three mouse models, of proteinuric CKD (POD-ATTAC), of ischemic CKD, and of unilateral urinary tract obstruction. We analyzed a cohort of patients who benefitted from renal catheterization and a retrospective cohort of patients hospitalized in the intensive care unit.

Results

Renal biopsies of CKD and kidney allograft patients revealed a stage-dependent de

SUBMITTER: Verissimo T 

PROVIDER: S-EPMC8970457 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature