Predicting late radiation-induced xerostomia with parotid gland PET biomarkers and dose metrics.

ABSTRACT:

Purpose

To assess associations between parotid gland PET biomarkers and late radiation-induced xerostomia, and to validate improvement of xerostomia predictive models by adding pre-treatment PET features to models based on dose and pre-treatment xerostomia.

Materials and methods

Intensity PET features from 47 patients treated on institutional prospective clinical trials for HPV-associated oropharyngeal squamous cell carcinoma with uniform chemoRT were analyzed. Associations between 90th percentile of the parotid gland standardized uptake values (P90) from pre-treatment and post-treatment PET scans, mean parotid gland doses, and late xerostomia defined by the Xerostomia Questionnaire (XQ) and salivary flow rates were quantified. Multivariable analysis was applied for dose and

SUBMITTER: Wilkie JR 

PROVIDER: S-EPMC8970466 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature