Association between miRNA-499 gene polymorphism and autoimmune diseases: A meta-analysis.

ABSTRACT:

Introduction

The association between miRNA-499 rs3746444 and a variety of autoimmune diseases has been reported. However, these results were contradictory and just focused on one or two autoimmune diseases. The present study aims to examine the possible association between rs3746444 polymorphism and the risk of autoimmune diseases.

Methods

The studies that evaluated the association between miRNA-499 gene polymorphism and autoimmune diseases were retrieved. Five different genetic models were used to evaluate the association. The random-effects model was used to pool the effect sizes. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the associations. Stratification analyses were performed by ethnicity and type of autoimmune diseases. False-posit

SUBMITTER: Kong X 

PROVIDER: S-EPMC8970500 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature